Disease State
Histology
Clinico-pathological Parameters
Survival
Subtype
TCGA Integrative Data

Description\Disease State	OSE	Normal Stroma	FTE	Tumor	Tumor Stroma	Peritoneal Tumor	FTE Tumor	Metastasis from elsewehre
Mean	5.60	5.85	5.19	5.95	5.84	5.95	6.21	5.90
Quantile 1	5.187	5.451	4.941	5.457	5.500	5.487	5.882	5.468
Median	5.429	5.813	5.168	5.949	5.800	6.024	6.243	5.817
Quantile 4	5.863	6.197	5.376	6.419	6.174	6.382	6.781	6.199

Mann Whitney Test	OSE	Normal Stroma	FTE	Tumor	Tumor Stroma	Peritoneal Tumor	FTE Tumor	Metastasis from elsewhere	Rest
OSE		2.73e-02	5.09e-02	1.92e-07	5.65e-03	7.81e-04	1.21e-03	1.68e-03	2.17e-07
Normal Stroma			2.15e-03	3.97e-01	8.98e-01	4.49e-01	4.80e-02	7.81e-01	4.66e-01
FTE				8.78e-04	6.19e-04	5.45e-04	2.17e-03	2.00e-03	9.29e-04
Tumor					2.82e-01	9.88e-01	9.52e-02	4.47e-01	1.34e-04
Tumor Stroma						3.96e-01	1.60e-02	7.98e-01	3.59e-01
Peritoneal Tumor							1.41e-01	6.21e-01	8.80e-01
FTE Tumor								5.71e-02	7.83e-02
Metastasis from elsewhere									5.56e-01

Abbreviation:OSE, Ovarian Surface Epithelium; FTE, Fallopian Tube; T_Stroma, Tumor Stroma

Description\Histology	Clear Cell	Endometrioid	Mucinous	Mucinous-LMP	Serous	Serous-LMP
Mean	6.209	6.018	6.084	5.968	5.921	5.790
Quantile 1	5.749	5.545	5.632	5.477	5.436	5.437
Median	6.281	6.027	6.087	5.884	5.920	5.751
Quantile 4	6.618	6.505	6.455	6.245	6.389	6.093

Mann Whitney Test	Clear Cell	Endometrioid	Mucinous	Mucinous-LMP	Serous	Serous-LMP	Rest
Clear Cell		3.14e-03	7.03e-02	9.27e-02	1.98e-07	1.25e-08	1.99e-07
Endometrioid			4.74e-01	5.79e-01	1.17e-01	2.63e-03	1.89e-01
Mucinous				4.07e-01	4.88e-02	7.92e-04	7.52e-02
Mucinous-LMP					8.97e-01	5.22e-01	8.19e-01
Serous						2.15e-02	1.58e-03
Serous-LMP							6.32e-03

Abbreviation:LMP, Low Malignant Potential

Stage

Description\Stage	I	II	III	IV
Mean	5.978	6.012	5.926	5.966
Quantile 1	5.510	5.539	5.435	5.405
Median	5.960	6.097	5.943	5.925
Quantile 4	6.412	6.453	6.399	6.477

Mann Whitney Test	I	II	III	IV	Rest
I		4.26e-01	3.95e-01	8.84e-01	2.74e-01
II			1.24e-01	4.44e-01	8.21e-02
III				5.16e-01	7.93e-01
IV					4.35e-01

Grade

Description\Grade	Grade 1	Grade 2	Grade 3
Mean	5.892	5.960	5.951
Quantile 1	5.443	5.492	5.432
Median	5.852	5.955	5.954
Quantile 4	6.188	6.419	6.431

Mann Whitney Test	Grade 1	Grade 2	Grade 3	Rest
Grade 1		2.05e-01	2.69e-01	3.86e-01
Grade 2			7.52e-01	2.87e-01
Grade 3				1.40e-01

Clinical Response

Description\Response	Sensitive	Resistant	Refractory
Mean	5.943	5.919	6.092
Quantile 1	5.394	5.424	5.569
Median	5.942	5.926	6.200
Quantile 4	6.474	6.369	6.616

Mann Whitney Test
Sensitive vs Rest, p = 00
Resistant vs Rest, p = 00
Refractory vs Rest, p = 6.04e-01

EMT Score

Spearman Correlation test
Rho = -0.004412
p = 7.96e-01

Age

Spearman Correlation test
Rho = 0.128565
p = 9.65e-08

Overall Survival(n = 1868)

Log-rank p = 0.0588
Median survival (Month),
BRCA1 < median = 50.30
BRCA1 >= median = 42.58
Hazard Ratio = 0.8869 (0.7830 - 1.004)

Overall Survival Q1vsQ4 (n = 934)

Log-rank p = 0.0459
Median survival (Month),
BRCA1_Q1 = 50.30
BRCA1_Q4 = 40.13
Hazard Ratio = 0.8329 (0.6961 - 0.9967)

Disease-Free Survival (n = 1516)

Log-rank p = 0.9075
Median survival (Month),
BRCA1 < median = 20.77
BRCA1 >= median = 20.56
Hazard Ratio = 0.9928 (0.8792 - 1.121)

Disease-Free Survival Q1vsQ4 (n = 758)

Log-rank p = 0.3954
Median survival (Month),
BRCA1_Q1 = 19.82
BRCA1_Q4 = 18.86
Hazard Ratio = 0.9286 (0.7829 - 1.102)

Multivariate Analysis - Overall Survival

Multivariate Analysis - Disease-Free Survival

Factor	Cox Coefficient	p-value
Stage	1.400161	0.000015
Grade	0.655603	0.088314
Surgical Debulking	0.200795	0.034283
Histology	1.300728	0.009946
Age	0.160587	0.077808
BRCA1	0.029595	0.744640

Factor	Cox Coefficient	p-value
Stage	1.283760	0.000000
Grade	0.308052	0.367858
Surgical Debulking	0.262593	0.005161
Histology	1.107184	0.000204
Age	0.202355	0.021395
BRCA1	-0.114293	0.193727

Subtype

Description\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
Mean	5.631	5.928	5.777	6.237	6.250
Quantile 1	5.265	5.436	5.324	5.791	5.836
Median	5.632	5.978	5.711	6.276	6.284
Quantile 4	5.981	6.430	6.183	6.680	6.662

Mann Whitney Test	Epi-A	Epi-B	Mes	Stem-A	Stem-B	Rest
Epi-A		5.56e-16	5.14e-04	1.54e-48	1.70e-35	8.63e-24
Epi-B			1.20e-09	1.63e-17	1.64e-11	5.76e-01
Mes				3.74e-47	2.28e-29	2.63e-23
Stem-A					8.44e-01	2.24e-38
Stem-B						2.04e-17

Subtype Overall Survival
Overall Survival Epi-A (n = 203)	Overall Survival Epi-B (n = 618)	Overall Survival Mes (n = 539)	Overall Survival Stem-A (n = 395)	Overall Survival Stem-B (n = 113)
Log-rank p = 0.1358 Median survival (Month), BRCA1 < median = 50.00 BRCA1 >= median = 66.57 Hazard Ratio = 1.367 (0.9065 - 2.062)	Log-rank p = 0.0829 Median survival (Month), BRCA1 < median = 54.83 BRCA1 >= median = 45.40 Hazard Ratio = 0.8231 (0.6605 - 1.026)	Log-rank p = 0.1210 Median survival (Month), BRCA1 < median = 44.13 BRCA1 >= median = 33.00 Hazard Ratio = 0.8359 (0.6665 - 1.048)	Log-rank p = 0.7724 Median survival (Month), BRCA1 < median = 38.00 BRCA1 >= median = 35.53 Hazard Ratio = 0.9630 (0.7462 - 1.243)	Log-rank p = 0.6804 Median survival (Month), BRCA1 < median = 118.0 BRCA1 >= median = Undefined Hazard Ratio = 1.146 (0.6001 - 2.187)


Subtype Disease-Free Survival
Disease-Free Survival Epi-A (n = 168)	Disease-Free Survival Epi-B (n = 496)	Disease-Free Survival Mes (n = 447)	Disease-Free Survival Stem-A (n = 305)	Disease-Free Survival Stem-B (n = 100)
Log-rank p = 0.1622 Median survival (Month), BRCA1 < median = 20.77 BRCA1 >= median = 33.53 Hazard Ratio = 1.332 (0.8912 - 1.990)	Log-rank p = 0.2295 Median survival (Month), BRCA1 < median = 22.02 BRCA1 >= median = 20.25 Hazard Ratio = 0.8800 (0.7143 - 1.084)	Log-rank p = 0.2840 Median survival (Month), BRCA1 < median = 17.43 BRCA1 >= median = 16.00 Hazard Ratio = 0.8879 (0.7143 - 1.104)	Log-rank p = 0.3777 Median survival (Month), BRCA1 < median = 21.59 BRCA1 >= median = 16.00 Hazard Ratio = 0.8880 (0.6819 - 1.156)	Log-rank p = 0.8855 Median survival (Month), BRCA1 < median = 100.8 BRCA1 >= median = Undefined Hazard Ratio = 1.049 (0.5453 - 2.019)

Subtype - Copy Number

Description\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
Mean	-0.477	-0.408	-0.303	-0.331	-0.133
Quantile 1	-0.620	-0.600	-0.488	-0.541	-0.249
Median	-0.478	-0.462	-0.324	-0.378	-0.031
Quantile 4	-0.282	-0.212	-0.102	-0.085	-0.017

Mann Whitney Test	Epi-A	Epi-B	Mes	Stem-A	Stem-B	Rest
Epi-A		2.83e-01	6.25e-04	1.58e-02	5.18e-02	1.07e-02
Epi-B			1.64e-03	5.54e-02	5.96e-02	2.05e-02
Mes				3.60e-01	1.93e-01	3.31e-03
Stem-A					2.02e-01	2.69e-01
Stem-B						1.09e-01

Subtype - Mutation

Mutation Status\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
(W)ild(T)ype (%)	53 (93.0)	152 (97.4)	128 (93.4)	105 (98.1)	4 (100.0)
Mutant (%)	4 (7.0)	4 (2.6)	9 (6.6)	2 (1.9)	0 (0.0)

Enrichment for mutant status
Fisher Exact Test:
Epi-A , 0.275
Epi-B, 0.323
Mes, 0.121
Stem-A, 0.268
Stem-B, 1.000

Subtype - DNA Methylation

Description\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
Mean	0.807	0.736	0.765	0.638	0.598
Quantile 1	0.808	0.621	0.700	0.320	0.351
Median	0.907	0.855	0.890	0.771	0.436
Quantile 4	0.941	0.931	0.942	0.917	0.945

Mann Whitney Test	Epi-A	Epi-B	Mes	Stem-A	Stem-B	Rest
Epi-A		4.20e-02	4.37e-01	1.95e-04	3.88e-01	1.96e-02
Epi-B			1.18e-01	8.60e-03	6.33e-01	8.64e-01
Mes				1.40e-04	4.28e-01	2.06e-02
Stem-A					8.94e-01	8.65e-05
Stem-B						6.33e-01

CSIOVDB - BRCA1

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