Disease State
Histology
Clinico-pathological Parameters
Survival
Subtype
TCGA Integrative Data

Description\Disease State	OSE	Normal Stroma	FTE	Tumor	Tumor Stroma	Peritoneal Tumor	FTE Tumor	Metastasis from elsewehre
Mean	9.97	10.37	8.30	10.22	9.71	9.82	10.41	9.86
Quantile 1	9.140	10.158	7.831	9.773	9.199	9.517	10.260	8.745
Median	10.362	10.397	8.249	10.375	9.950	10.145	10.502	10.198
Quantile 4	11.104	10.663	8.769	10.900	10.521	10.581	10.924	10.915

Mann Whitney Test	OSE	Normal Stroma	FTE	Tumor	Tumor Stroma	Peritoneal Tumor	FTE Tumor	Metastasis from elsewhere	Rest
OSE		6.64e-01	1.45e-03	4.15e-01	1.59e-01	4.07e-01	4.50e-01	4.92e-01	5.15e-01
Normal Stroma			3.23e-05	9.29e-01	2.23e-02	6.11e-02	4.98e-01	3.99e-01	8.31e-01
FTE				1.83e-05	2.72e-03	1.57e-04	7.02e-04	2.53e-03	2.50e-05
Tumor					3.95e-03	1.77e-02	4.59e-01	1.43e-01	8.28e-05
Tumor Stroma						3.96e-01	2.77e-02	2.35e-01	5.82e-03
Peritoneal Tumor							6.15e-02	5.60e-01	2.65e-02
FTE Tumor								2.46e-01	4.13e-01
Metastasis from elsewhere									1.84e-01

Abbreviation:OSE, Ovarian Surface Epithelium; FTE, Fallopian Tube; T_Stroma, Tumor Stroma

Description\Histology	Clear Cell	Endometrioid	Mucinous	Mucinous-LMP	Serous	Serous-LMP
Mean	11.011	10.259	10.624	10.596	10.149	10.589
Quantile 1	10.715	9.843	10.170	10.484	9.726	10.277
Median	11.269	10.368	10.962	10.598	10.293	10.746
Quantile 4	11.696	10.828	11.292	10.858	10.797	11.138

Mann Whitney Test	Clear Cell	Endometrioid	Mucinous	Mucinous-LMP	Serous	Serous-LMP	Rest
Clear Cell		1.50e-16	5.77e-04	2.85e-02	3.38e-28	1.05e-07	5.25e-27
Endometrioid			3.82e-06	2.04e-01	2.86e-01	5.19e-05	8.45e-01
Mucinous				2.65e-01	1.27e-08	1.03e-01	4.57e-07
Mucinous-LMP					1.21e-01	7.61e-01	2.28e-01
Serous						4.12e-08	7.40e-26
Serous-LMP							4.21e-06

Abbreviation:LMP, Low Malignant Potential

Stage

Description\Stage	I	II	III	IV
Mean	10.478	10.392	10.117	10.185
Quantile 1	10.074	9.904	9.715	9.774
Median	10.729	10.566	10.257	10.385
Quantile 4	11.151	11.041	10.785	10.825

Mann Whitney Test	I	II	III	IV	Rest
I		1.40e-01	9.95e-12	2.94e-05	1.19e-09
II			3.83e-04	3.35e-02	8.50e-03
III				1.44e-01	7.90e-07
IV					9.56e-01

Grade

Description\Grade	Grade 1	Grade 2	Grade 3
Mean	10.445	10.390	10.081
Quantile 1	9.961	9.980	9.678
Median	10.842	10.455	10.256
Quantile 4	11.140	10.931	10.761

Mann Whitney Test	Grade 1	Grade 2	Grade 3	Rest
Grade 1		3.52e-02	4.43e-06	2.95e-04
Grade 2			2.48e-07	4.40e-04
Grade 3				1.81e-09

Clinical Response

Description\Response	Sensitive	Resistant	Refractory
Mean	10.208	10.137	10.029
Quantile 1	9.699	9.752	9.401
Median	10.345	10.325	10.151
Quantile 4	10.861	10.852	10.963

Mann Whitney Test
Sensitive vs Rest, p = 00
Resistant vs Rest, p = 00
Refractory vs Rest, p = 7.47e-01

EMT Score

Spearman Correlation test
Rho = -0.320422
p = 6.64e-83

Age

Spearman Correlation test
Rho = -0.066745
p = 5.77e-03

Overall Survival(n = 1868)

Log-rank p = 0.2098
Median survival (Month),
CDH1 < median = 45.40
CDH1 >= median = 49.00
Hazard Ratio = 1.083 (0.9561 - 1.227)

Overall Survival Q1vsQ4 (n = 934)

Log-rank p = 0.0088
Median survival (Month),
CDH1_Q1 = 37.00
CDH1_Q4 = 50.97
Hazard Ratio = 1.263 (1.061 - 1.504)

Disease-Free Survival (n = 1516)

Log-rank p = 0.5185
Median survival (Month),
CDH1 < median = 19.82
CDH1 >= median = 21.03
Hazard Ratio = 1.041 (0.9217 - 1.176)

Disease-Free Survival Q1vsQ4 (n = 758)

Log-rank p = 0.0212
Median survival (Month),
CDH1_Q1 = 18.30
CDH1_Q4 = 22.23
Hazard Ratio = 1.226 (1.031 - 1.458)

Multivariate Analysis - Overall Survival

Multivariate Analysis - Disease-Free Survival

Factor	Cox Coefficient	p-value
Stage	1.403239	0.000014
Grade	0.645729	0.093133
Surgical Debulking	0.197842	0.037258
Histology	1.292684	0.010456
Age	0.160512	0.077699
CDH1	-0.048115	0.596599

Factor	Cox Coefficient	p-value
Stage	1.285548	0.000000
Grade	0.285784	0.403765
Surgical Debulking	0.270368	0.004023
Histology	1.116408	0.000184
Age	0.198742	0.023460
CDH1	0.122277	0.163237

Subtype

Description\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
Mean	10.503	10.294	9.804	10.155	10.700
Quantile 1	10.135	9.879	9.301	9.738	10.286
Median	10.644	10.380	10.092	10.373	11.016
Quantile 4	10.987	10.844	10.630	10.890	11.551

Mann Whitney Test	Epi-A	Epi-B	Mes	Stem-A	Stem-B	Rest
Epi-A		7.27e-07	1.22e-28	3.31e-06	1.29e-09	1.73e-10
Epi-B			2.06e-19	5.86e-01	1.56e-20	1.82e-01
Mes				3.64e-12	4.08e-37	7.15e-38
Stem-A					5.65e-19	8.92e-01
Stem-B						3.00e-28

Subtype Overall Survival
Overall Survival Epi-A (n = 203)	Overall Survival Epi-B (n = 618)	Overall Survival Mes (n = 539)	Overall Survival Stem-A (n = 395)	Overall Survival Stem-B (n = 113)
Log-rank p = 0.1462 Median survival (Month), CDH1 < median = 53.27 CDH1 >= median = 69.00 Hazard Ratio = 1.354 (0.8998 - 2.036)	Log-rank p = 0.0545 Median survival (Month), CDH1 < median = 56.23 CDH1 >= median = 45.63 Hazard Ratio = 0.8066 (0.6479 - 1.004)	Log-rank p = 0.7260 Median survival (Month), CDH1 < median = 37.07 CDH1 >= median = 39.93 Hazard Ratio = 0.9604 (0.7660 - 1.204)	Log-rank p = 0.1736 Median survival (Month), CDH1 < median = 36.01 CDH1 >= median = 39.63 Hazard Ratio = 1.194 (0.9248 - 1.542)	Log-rank p = 0.5888 Median survival (Month), CDH1 < median = 118.0 CDH1 >= median = Undefined Hazard Ratio = 1.195 (0.6257 - 2.284)


Subtype Disease-Free Survival
Disease-Free Survival Epi-A (n = 168)	Disease-Free Survival Epi-B (n = 496)	Disease-Free Survival Mes (n = 447)	Disease-Free Survival Stem-A (n = 305)	Disease-Free Survival Stem-B (n = 100)
Log-rank p = 0.0016 Median survival (Month), CDH1 < median = 18.23 CDH1 >= median = 47.94 Hazard Ratio = 1.922 (1.280 - 2.884)	Log-rank p = 0.0243 Median survival (Month), CDH1 < median = 24.00 CDH1 >= median = 19.27 Hazard Ratio = 0.7870 (0.6389 - 0.9694)	Log-rank p = 0.0854 Median survival (Month), CDH1 < median = 18.00 CDH1 >= median = 15.00 Hazard Ratio = 0.8258 (0.6641 - 1.027)	Log-rank p = 0.8627 Median survival (Month), CDH1 < median = 18.30 CDH1 >= median = 20.00 Hazard Ratio = 1.024 (0.7864 - 1.332)	Log-rank p = 0.5493 Median survival (Month), CDH1 < median = 100.8 CDH1 >= median = Undefined Hazard Ratio = 1.222 (0.6343 - 2.353)

Subtype - Copy Number

Description\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
Mean	-0.337	-0.435	-0.397	-0.476	-0.134
Quantile 1	-0.670	-0.650	-0.583	-0.719	-0.265
Median	-0.401	-0.482	-0.416	-0.487	-0.019
Quantile 4	0.036	-0.211	-0.202	-0.203	-0.004

Mann Whitney Test	Epi-A	Epi-B	Mes	Stem-A	Stem-B	Rest
Epi-A		1.31e-01	4.97e-01	7.35e-02	5.00e-01	1.49e-01
Epi-B			1.16e-01	5.97e-01	6.38e-02	2.57e-01
Mes				8.26e-02	9.93e-02	1.89e-01
Stem-A					9.35e-02	1.14e-01
Stem-B						1.04e-01

Subtype - Mutation

Mutation Status\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
(W)ild(T)ype (%)	57 (100.0)	155 (99.4)	136 (99.3)	107 (100.0)	4 (100.0)
Mutant (%)	0 (0.0)	1 (0.6)	1 (0.7)	0 (0.0)	0 (0.0)

Enrichment for mutant status
Fisher Exact Test:
Epi-A , 1.000
Epi-B, 1.000
Mes, 0.506
Stem-A, 1.000
Stem-B, 1.000

Subtype - DNA Methylation

Description\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
Mean	0.116	0.174	0.199	0.076	0.068
Quantile 1	0.055	0.077	0.109	0.018	0.024
Median	0.087	0.140	0.176	0.043	0.071
Quantile 4	0.167	0.229	0.266	0.106	0.098

Mann Whitney Test	Epi-A	Epi-B	Mes	Stem-A	Stem-B	Rest
Epi-A		2.94e-04	2.35e-08	2.36e-05	2.49e-01	2.41e-02
Epi-B			6.16e-03	1.49e-18	2.74e-02	1.36e-04
Mes				3.55e-24	4.46e-03	1.89e-13
Stem-A					7.40e-01	6.80e-24
Stem-B						9.14e-02

CSIOVDB - CDH1

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