Disease State
Histology
Clinico-pathological Parameters
Survival
Subtype
TCGA Integrative Data

Description\Disease State	OSE	Normal Stroma	FTE	Tumor	Tumor Stroma	Peritoneal Tumor	FTE Tumor	Metastasis from elsewehre
Mean	9.29	8.73	7.89	8.85	9.07	9.06	8.84	8.72
Quantile 1	8.688	8.164	7.383	8.300	8.706	8.517	8.560	8.102
Median	9.366	8.395	8.157	8.818	9.048	8.976	9.009	8.631
Quantile 4	9.808	9.125	8.330	9.386	9.544	9.612	9.074	9.248

Mann Whitney Test	OSE	Normal Stroma	FTE	Tumor	Tumor Stroma	Peritoneal Tumor	FTE Tumor	Metastasis from elsewhere	Rest
OSE		6.37e-03	1.82e-04	4.62e-06	2.86e-01	1.06e-01	4.95e-02	1.53e-04	5.29e-06
Normal Stroma			7.09e-02	2.17e-01	6.90e-02	5.06e-02	1.61e-01	7.67e-01	1.96e-01
FTE				2.16e-03	1.33e-03	5.00e-04	1.40e-03	1.31e-02	1.95e-03
Tumor					8.18e-02	8.22e-02	8.20e-01	1.64e-01	9.92e-03
Tumor Stroma						7.52e-01	3.47e-01	3.02e-02	9.60e-02
Peritoneal Tumor							5.06e-01	3.87e-02	1.01e-01
FTE Tumor								3.28e-01	8.68e-01
Metastasis from elsewhere									1.27e-01

Abbreviation:OSE, Ovarian Surface Epithelium; FTE, Fallopian Tube; T_Stroma, Tumor Stroma

Description\Histology	Clear Cell	Endometrioid	Mucinous	Mucinous-LMP	Serous	Serous-LMP
Mean	8.983	8.831	8.598	8.673	8.877	8.483
Quantile 1	8.472	8.221	7.944	7.994	8.328	7.920
Median	8.847	8.823	8.533	8.903	8.853	8.419
Quantile 4	9.502	9.345	9.007	9.190	9.401	9.042

Mann Whitney Test	Clear Cell	Endometrioid	Mucinous	Mucinous-LMP	Serous	Serous-LMP	Rest
Clear Cell		1.10e-01	7.16e-04	3.24e-01	1.94e-01	4.88e-06	9.01e-02
Endometrioid			1.95e-02	6.03e-01	4.06e-01	6.34e-04	6.04e-01
Mucinous				6.76e-01	1.07e-03	3.59e-01	1.83e-03
Mucinous-LMP					4.21e-01	4.19e-01	4.80e-01
Serous						9.25e-07	1.74e-03
Serous-LMP							1.43e-06

Abbreviation:LMP, Low Malignant Potential

Stage

Description\Stage	I	II	III	IV
Mean	8.792	8.955	8.871	8.880
Quantile 1	8.170	8.352	8.305	8.365
Median	8.756	8.858	8.841	8.849
Quantile 4	9.337	9.527	9.407	9.370

Mann Whitney Test	I	II	III	IV	Rest
I		9.13e-02	1.79e-01	2.23e-01	1.14e-01
II			3.23e-01	4.75e-01	3.01e-01
III				8.78e-01	9.24e-01
IV					8.65e-01

Grade

Description\Grade	Grade 1	Grade 2	Grade 3
Mean	8.690	8.807	8.923
Quantile 1	7.934	8.288	8.374
Median	8.479	8.749	8.902
Quantile 4	9.399	9.316	9.451

Mann Whitney Test	Grade 1	Grade 2	Grade 3	Rest
Grade 1		5.44e-02	1.48e-03	5.50e-03
Grade 2			4.29e-03	5.25e-02
Grade 3				3.78e-04

Clinical Response

Description\Response	Sensitive	Resistant	Refractory
Mean	8.858	8.861	8.959
Quantile 1	8.341	8.244	8.405
Median	8.824	8.865	8.995
Quantile 4	9.408	9.424	9.406

Mann Whitney Test
Sensitive vs Rest, p = 00
Resistant vs Rest, p = 00
Refractory vs Rest, p = 8.76e-01

EMT Score

Spearman Correlation test
Rho = -0.029016
p = 8.90e-02

Age

Spearman Correlation test
Rho = -0.072012
p = 2.90e-03

Overall Survival(n = 1868)

Log-rank p = 0.5558
Median survival (Month),
NAMPT < median = 48.00
NAMPT >= median = 46.13
Hazard Ratio = 0.9632 (0.8502 - 1.091)

Overall Survival Q1vsQ4 (n = 934)

Log-rank p = 0.8650
Median survival (Month),
NAMPT_Q1 = 49.57
NAMPT_Q4 = 48.00
Hazard Ratio = 0.9847 (0.8248 - 1.176)

Disease-Free Survival (n = 1516)

Log-rank p = 0.5084
Median survival (Month),
NAMPT < median = 20.97
NAMPT >= median = 20.00
Hazard Ratio = 0.9598 (0.8499 - 1.084)

Disease-Free Survival Q1vsQ4 (n = 758)

Log-rank p = 0.1862
Median survival (Month),
NAMPT_Q1 = 23.00
NAMPT_Q4 = 20.00
Hazard Ratio = 0.8899 (0.7485 - 1.058)

Multivariate Analysis - Overall Survival

Multivariate Analysis - Disease-Free Survival

Factor	Cox Coefficient	p-value
Stage	1.408866	0.000013
Grade	0.636310	0.098023
Surgical Debulking	0.192704	0.042721
Histology	1.319720	0.008933
Age	0.174683	0.056485
NAMPT	0.104469	0.258113

Factor	Cox Coefficient	p-value
Stage	1.287644	0.000000
Grade	0.301220	0.378143
Surgical Debulking	0.248284	0.008394
Histology	1.107829	0.000198
Age	0.202643	0.020933
NAMPT	0.160683	0.068635

Subtype

Description\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
Mean	8.788	8.989	9.051	8.497	8.760
Quantile 1	8.164	8.450	8.446	8.027	8.083
Median	8.766	8.979	9.011	8.524	8.709
Quantile 4	9.379	9.467	9.588	8.958	9.277

Mann Whitney Test	Epi-A	Epi-B	Mes	Stem-A	Stem-B	Rest
Epi-A		3.63e-05	1.19e-06	1.07e-07	5.05e-01	6.20e-02
Epi-B			1.33e-01	9.97e-37	2.48e-06	9.80e-10
Mes				1.44e-37	1.74e-07	1.91e-15
Stem-A					3.88e-05	2.26e-37
Stem-B						8.90e-03

Subtype Overall Survival
Overall Survival Epi-A (n = 203)	Overall Survival Epi-B (n = 618)	Overall Survival Mes (n = 539)	Overall Survival Stem-A (n = 395)	Overall Survival Stem-B (n = 113)
Log-rank p = 0.3274 Median survival (Month), NAMPT < median = 65.17 NAMPT >= median = 56.17 Hazard Ratio = 0.8174 (0.5461 - 1.224)	Log-rank p = 0.2089 Median survival (Month), NAMPT < median = 54.00 NAMPT >= median = 48.00 Hazard Ratio = 0.8687 (0.6975 - 1.082)	Log-rank p = 0.9972 Median survival (Month), NAMPT < median = 39.93 NAMPT >= median = 38.47 Hazard Ratio = 0.9996 (0.7965 - 1.254)	Log-rank p = 0.9341 Median survival (Month), NAMPT < median = 36.00 NAMPT >= median = 38.60 Hazard Ratio = 0.9893 (0.7667 - 1.277)	Log-rank p = 0.1916 Median survival (Month), NAMPT < median = 118.0 NAMPT >= median = Undefined Hazard Ratio = 1.542 (0.8051 - 2.952)


Subtype Disease-Free Survival
Disease-Free Survival Epi-A (n = 168)	Disease-Free Survival Epi-B (n = 496)	Disease-Free Survival Mes (n = 447)	Disease-Free Survival Stem-A (n = 305)	Disease-Free Survival Stem-B (n = 100)
Log-rank p = 0.3337 Median survival (Month), NAMPT < median = 38.97 NAMPT >= median = 20.07 Hazard Ratio = 0.8213 (0.5510 - 1.224)	Log-rank p = 0.2174 Median survival (Month), NAMPT < median = 22.63 NAMPT >= median = 21.00 Hazard Ratio = 0.8768 (0.7114 - 1.081)	Log-rank p = 0.7749 Median survival (Month), NAMPT < median = 15.60 NAMPT >= median = 18.10 Hazard Ratio = 1.032 (0.8299 - 1.284)	Log-rank p = 0.8087 Median survival (Month), NAMPT < median = 18.37 NAMPT >= median = 20.00 Hazard Ratio = 1.033 (0.7936 - 1.345)	Log-rank p = 0.0300 Median survival (Month), NAMPT < median = 83.10 NAMPT >= median = Undefined Hazard Ratio = 2.067 (1.073 - 3.981)

Subtype - Copy Number

Description\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
Mean	0.209	0.229	0.104	0.170	0.160
Quantile 1	0.069	0.114	-0.017	0.018	0.029
Median	0.157	0.202	0.099	0.175	0.160
Quantile 4	0.395	0.394	0.267	0.367	0.290

Mann Whitney Test	Epi-A	Epi-B	Mes	Stem-A	Stem-B	Rest
Epi-A		4.18e-01	1.65e-02	5.01e-01	5.69e-01	4.41e-01
Epi-B			2.46e-05	1.23e-01	5.02e-01	1.49e-03
Mes				4.33e-02	7.42e-01	1.41e-04
Stem-A					8.85e-01	9.64e-01
Stem-B						8.04e-01

Subtype - Mutation

Mutation Status\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
(W)ild(T)ype (%)	57 (100.0)	156 (100.0)	137 (100.0)	106 (99.1)	4 (100.0)
Mutant (%)	0 (0.0)	0 (0.0)	0 (0.0)	1 (0.9)	0 (0.0)

Enrichment for mutant status
Fisher Exact Test:
Epi-A , 1.000
Epi-B, 1.000
Mes, 1.000
Stem-A, 0.232
Stem-B, 1.000

No Methylation data

CSIOVDB - NAMPT

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