Disease State
Histology
Clinico-pathological Parameters
Survival
Subtype
TCGA Integrative Data

Description\Disease State	OSE	Normal Stroma	FTE	Tumor	Tumor Stroma	Peritoneal Tumor	FTE Tumor	Metastasis from elsewehre
Mean	6.90	7.36	6.34	7.72	8.71	8.63	7.78	6.61
Quantile 1	5.917	6.356	5.803	6.218	7.011	7.580	5.978	5.662
Median	6.794	7.054	6.128	7.599	9.212	9.028	7.844	6.042
Quantile 4	7.769	8.763	6.451	9.108	10.308	9.918	9.827	7.451

Mann Whitney Test	OSE	Normal Stroma	FTE	Tumor	Tumor Stroma	Peritoneal Tumor	FTE Tumor	Metastasis from elsewhere	Rest
OSE		1.81e-01	1.31e-01	3.77e-05	7.67e-06	2.41e-09	1.42e-01	4.75e-02	4.75e-05
Normal Stroma			2.80e-02	4.02e-01	5.62e-03	1.49e-03	6.55e-01	1.29e-02	4.50e-01
FTE				2.49e-02	3.66e-03	7.02e-04	1.29e-01	8.55e-01	2.67e-02
Tumor					1.99e-03	2.13e-04	8.65e-01	4.02e-07	9.68e-03
Tumor Stroma						7.12e-01	1.39e-01	9.33e-07	1.40e-03
Peritoneal Tumor							1.58e-01	4.84e-10	1.06e-04
FTE Tumor								3.93e-02	8.28e-01
Metastasis from elsewhere									3.83e-07

Abbreviation:OSE, Ovarian Surface Epithelium; FTE, Fallopian Tube; T_Stroma, Tumor Stroma

Description\Histology	Clear Cell	Endometrioid	Mucinous	Mucinous-LMP	Serous	Serous-LMP
Mean	9.068	6.803	6.227	5.993	7.812	7.395
Quantile 1	7.473	5.766	5.465	5.221	6.323	5.967
Median	9.303	6.456	6.088	5.716	7.781	7.511
Quantile 4	10.619	7.489	6.742	6.063	9.203	8.457

Mann Whitney Test	Clear Cell	Endometrioid	Mucinous	Mucinous-LMP	Serous	Serous-LMP	Rest
Clear Cell		6.33e-22	1.43e-20	1.81e-05	8.03e-13	5.46e-10	3.15e-15
Endometrioid			2.44e-03	2.56e-02	6.91e-14	2.41e-03	2.21e-13
Mucinous				1.97e-01	1.38e-15	8.30e-07	6.67e-15
Mucinous-LMP					6.08e-04	6.76e-03	8.53e-04
Serous						2.12e-02	9.65e-07
Serous-LMP							5.71e-02

Abbreviation:LMP, Low Malignant Potential

Stage

Description\Stage	I	II	III	IV
Mean	7.447	7.206	7.785	7.936
Quantile 1	5.840	5.532	6.319	6.615
Median	7.151	6.892	7.713	7.894
Quantile 4	8.714	8.647	9.213	9.284

Mann Whitney Test	I	II	III	IV	Rest
I		1.92e-01	6.92e-04	3.47e-04	4.77e-03
II			3.47e-05	1.76e-05	1.68e-04
III				2.03e-01	3.01e-04
IV					9.25e-03

Grade

Description\Grade	Grade 1	Grade 2	Grade 3
Mean	7.129	7.703	7.776
Quantile 1	5.599	6.273	6.265
Median	6.742	7.526	7.755
Quantile 4	8.198	9.048	9.212

Mann Whitney Test	Grade 1	Grade 2	Grade 3	Rest
Grade 1		1.14e-03	1.27e-04	3.67e-04
Grade 2			4.21e-01	7.61e-01
Grade 3				3.48e-03

Clinical Response

Description\Response	Sensitive	Resistant	Refractory
Mean	7.714	7.816	7.637
Quantile 1	6.176	6.293	6.395
Median	7.609	7.827	7.623
Quantile 4	9.123	9.214	8.795

Mann Whitney Test
Sensitive vs Rest, p = 00
Resistant vs Rest, p = 00
Refractory vs Rest, p = 4.70e-01

EMT Score

Spearman Correlation test
Rho = 0.167198
p = 5.72e-23

Age

Spearman Correlation test
Rho = 0.059588
p = 1.37e-02

Overall Survival(n = 1868)

Log-rank p = 0.0053
Median survival (Month),
MFAP5 < median = 49.47
MFAP5 >= median = 43.93
Hazard Ratio = 0.8374 (0.7391 - 0.9487)

Overall Survival Q1vsQ4 (n = 934)

Log-rank p = 0.0012
Median survival (Month),
MFAP5_Q1 = 53.27
MFAP5_Q4 = 42.13
Hazard Ratio = 0.7451 (0.6240 - 0.8898)

Disease-Free Survival (n = 1516)

Log-rank p = 0.0012
Median survival (Month),
MFAP5 < median = 23.00
MFAP5 >= median = 18.43
Hazard Ratio = 0.8174 (0.7236 - 0.9235)

Disease-Free Survival Q1vsQ4 (n = 758)

Log-rank p = <
Median survival (Month),
MFAP5_Q1 = 26.16
MFAP5_Q4 = 17.03
Hazard Ratio = 0.6921 (0.5819 - 0.8231)

Multivariate Analysis - Overall Survival

Multivariate Analysis - Disease-Free Survival

Factor	Cox Coefficient	p-value
Stage	1.400710	0.000015
Grade	0.651099	0.090676
Surgical Debulking	0.200360	0.034662
Histology	1.301374	0.009910
Age	0.162150	0.076272
MFAP5	0.000210	0.998170

Factor	Cox Coefficient	p-value
Stage	1.260288	0.000000
Grade	0.316365	0.354936
Surgical Debulking	0.249047	0.008148
Histology	1.092786	0.000245
Age	0.178788	0.041797
MFAP5	0.164421	0.062548

Subtype

Description\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
Mean	7.315	7.244	8.484	7.498	7.537
Quantile 1	5.967	6.007	7.134	6.180	5.764
Median	7.090	6.975	8.829	7.332	6.905
Quantile 4	8.460	8.263	9.817	8.704	9.182

Mann Whitney Test	Epi-A	Epi-B	Mes	Stem-A	Stem-B	Rest
Epi-A		4.91e-01	3.99e-30	7.85e-02	8.38e-01	6.58e-06
Epi-B			2.84e-58	1.58e-03	5.62e-01	1.26e-21
Mes				2.71e-31	4.84e-15	4.99e-66
Stem-A					2.33e-01	2.66e-03
Stem-B						4.78e-03

Subtype Overall Survival
Overall Survival Epi-A (n = 203)	Overall Survival Epi-B (n = 618)	Overall Survival Mes (n = 539)	Overall Survival Stem-A (n = 395)	Overall Survival Stem-B (n = 113)
Log-rank p = 0.7529 Median survival (Month), MFAP5 < median = 56.17 MFAP5 >= median = 65.17 Hazard Ratio = 1.067 (0.7116 - 1.601)	Log-rank p = 0.4553 Median survival (Month), MFAP5 < median = 48.37 MFAP5 >= median = 49.47 Hazard Ratio = 0.9200 (0.7391 - 1.145)	Log-rank p = 0.1804 Median survival (Month), MFAP5 < median = 41.60 MFAP5 >= median = 33.00 Hazard Ratio = 0.8568 (0.6834 - 1.074)	Log-rank p = 0.2807 Median survival (Month), MFAP5 < median = 38.57 MFAP5 >= median = 36.77 Hazard Ratio = 0.8686 (0.6725 - 1.122)	Log-rank p = 0.4431 Median survival (Month), MFAP5 < median = 118.0 MFAP5 >= median = Undefined Hazard Ratio = 1.288 (0.6744 - 2.461)


Subtype Disease-Free Survival
Disease-Free Survival Epi-A (n = 168)	Disease-Free Survival Epi-B (n = 496)	Disease-Free Survival Mes (n = 447)	Disease-Free Survival Stem-A (n = 305)	Disease-Free Survival Stem-B (n = 100)
Log-rank p = 0.3996 Median survival (Month), MFAP5 < median = 30.87 MFAP5 >= median = 26.77 Hazard Ratio = 1.186 (0.7978 - 1.762)	Log-rank p = 0.1120 Median survival (Month), MFAP5 < median = 24.00 MFAP5 >= median = 19.05 Hazard Ratio = 0.8449 (0.6864 - 1.040)	Log-rank p = 0.0078 Median survival (Month), MFAP5 < median = 19.35 MFAP5 >= median = 13.38 Hazard Ratio = 0.7428 (0.5968 - 0.9246)	Log-rank p = 0.3478 Median survival (Month), MFAP5 < median = 21.20 MFAP5 >= median = 18.00 Hazard Ratio = 0.8816 (0.6778 - 1.147)	Log-rank p = 0.4833 Median survival (Month), MFAP5 < median = Undefined MFAP5 >= median = 100.8 Hazard Ratio = 0.7910 (0.4106 - 1.524)

Subtype - Copy Number

Description\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
Mean	0.209	0.241	0.155	0.434	0.220
Quantile 1	0.045	0.090	0.006	0.173	-0.000
Median	0.207	0.216	0.161	0.351	0.170
Quantile 4	0.422	0.387	0.373	0.639	0.439

Mann Whitney Test	Epi-A	Epi-B	Mes	Stem-A	Stem-B	Rest
Epi-A		6.22e-01	4.19e-01	1.08e-03	8.84e-01	3.34e-01
Epi-B			7.37e-02	8.84e-05	8.05e-01	4.61e-01
Mes				9.97e-07	9.57e-01	1.07e-03
Stem-A					2.91e-01	4.29e-07
Stem-B						7.22e-01

No Mutation data

Subtype - DNA Methylation

Description\Subtype	Epi-A	Epi-B	Mes	Stem-A	Stem-B
Mean	0.382	0.356	0.381	0.524	0.413
Quantile 1	0.156	0.127	0.177	0.259	0.121
Median	0.346	0.270	0.351	0.527	0.282
Quantile 4	0.567	0.564	0.560	0.790	0.799

Mann Whitney Test	Epi-A	Epi-B	Mes	Stem-A	Stem-B	Rest
Epi-A		4.16e-01	8.48e-01	8.66e-04	9.82e-01	4.63e-01
Epi-B			1.57e-01	5.18e-08	8.10e-01	4.11e-04
Mes				8.20e-06	9.64e-01	3.13e-01
Stem-A					4.00e-01	1.77e-08
Stem-B						9.17e-01

CSIOVDB - MFAP5

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